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Well differentiated papillary mesothelioma

MedGen UID:
234487
•Concept ID:
C1337012
•
Neoplastic Process
Synonyms: benign intermediate mesothelioma; benign/Intermediate mesothelioma; WDPM; Well Differentiated Papillary Mesothelial Tumor; well differentiated papillary mesothelioma; Well-Differentiated Mesothelial Papillary Neoplasm; well-differentiated mesothelial papillary neoplasm; Well-Differentiated Mesothelial Papillary Tumor; well-differentiated mesothelial papillary tumor; well-differentiated mesothelial papillary tumour; Well-Differentiated Papillary Mesothelial Tumor; Well-differentiated papillary mesothelioma; Well-Differentiated Papillary Neoplasm of Mesothelium; well-differentiated papillary neoplasm of mesothelium; Well-Differentiated Papillary Neoplasm of the Mesothelium; well-differentiated papillary neoplasm of the mesothelium; Well-Differentiated Papillary Tumor of Mesothelium; well-differentiated papillary tumor of mesothelium; Well-Differentiated Papillary Tumor of the Mesothelium; well-differentiated papillary tumor of the mesothelium; well-differentiated papillary tumour of mesothelium; well-differentiated papillary tumour of the mesothelium
SNOMED CT: Well-differentiated papillary mesothelioma (734100004)
 
Monarch Initiative: MONDO:0003688

Definition

A localized or multifocal mesothelial neoplasm arising from the peritoneum and less often the pleura and paratesticular region. Cases arising from the peritoneum predominantly occur in women. It is characterized by the formation of papillae, covered by a single layer of blunt mesothelial cells. Mitotic figures are not present. There is no evidence of severe cytologic atypia. It has a relatively favorable clinical outcome, compared to malignant mesothelioma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWell differentiated papillary mesothelioma

Professional guidelines

PubMed

SOX6 Expression Is Sensitive for Peritoneal Epithelioid Malignant Mesothelioma, But Not Specific in the Differential Diagnosis With Tubo-ovarian Serous Neoplasia.
Chapel DB, Hirsch MS
Am J Surg Pathol 2022 Feb 1;46(2):213-219. doi: 10.1097/PAS.0000000000001792. PMID: 34411029
Adenomatoid Tumor: A Review of Pathology With Focus on Unusual Presentations and Sites, Histogenesis, Differential Diagnosis, and Molecular and Clinical Aspects With a Historic Overview of Its Description.
Karpathiou G, Hiroshima K, Peoc'h M
Adv Anat Pathol 2020 Nov;27(6):394-407. doi: 10.1097/PAP.0000000000000278. PMID: 32769378
Pathohistological diagnosis and differential diagnosis.
Tischoff I, Neid M, Neumann V, Tannapfel A
Recent Results Cancer Res 2011;189:57-78. doi: 10.1007/978-3-642-10862-4_5. PMID: 21479896

Recent clinical studies

Etiology

Solid papillary mesothelial tumor.
Churg A, Le Stang N, Dacic S, Pissaloux D, Begueret H, Dartigues P, Giusiano-Courcambeck S, Sequeiros R, Pairon JC, Tirode F, Galateau-Sallé F
Mod Pathol 2022 Jan;35(1):69-76. Epub 2021 Sep 3 doi: 10.1038/s41379-021-00899-3. PMID: 34480081
Mesothelioma of the tunica vaginalis testis.
Butnor KJ, Pavlisko EN, Sporn TA, Roggli VL
Hum Pathol 2019 Oct;92:48-58. Epub 2019 Aug 1 doi: 10.1016/j.humpath.2019.07.009. PMID: 31376434
Well-Differentiated Papillary Mesothelioma of the Peritoneum: A Retrospective Study from the RENAPE Observational Registry.
Vogin G, Hettal L, Vignaud JM, Dartigues P, Goere D, Ferron G, Heyd B, Bereder JM, Tuech JJ, Glehen O, de Chaisemartin C, Lherm Y, Villeneuve L, Kepenekian V, Marchal F; RENAPE Network
Ann Surg Oncol 2019 Mar;26(3):852-860. Epub 2019 Jan 11 doi: 10.1245/s10434-018-07153-2. PMID: 30635798
Therapeutic strategies for well-differentiated papillary mesothelioma of the peritoneum.
Lee YK, Jun HJ, Nahm JH, Lim TS, Park JS, Ahn JB, Rha SY, Chung HC, Oh HE, Song JS, Yang WI, Kim HS
Jpn J Clin Oncol 2013 Oct;43(10):996-1003. Epub 2013 Aug 20 doi: 10.1093/jjco/hyt117. PMID: 23964112
Pathohistological diagnosis and differential diagnosis.
Tischoff I, Neid M, Neumann V, Tannapfel A
Recent Results Cancer Res 2011;189:57-78. doi: 10.1007/978-3-642-10862-4_5. PMID: 21479896

Diagnosis

Peritoneal Mesothelioma-An Update.
Malpica A
Adv Anat Pathol 2023 Jul 1;30(4):262-274. Epub 2022 Dec 12 doi: 10.1097/PAP.0000000000000387. PMID: 36729766
The 2021 WHO Classification of Tumors of the Pleura: Advances Since the 2015 Classification.
Sauter JL, Dacic S, Galateau-Salle F, Attanoos RL, Butnor KJ, Churg A, Husain AN, Kadota K, Khoor A, Nicholson AG, Roggli V, Schmitt F, Tsao MS, Travis WD
J Thorac Oncol 2022 May;17(5):608-622. Epub 2022 Jan 10 doi: 10.1016/j.jtho.2021.12.014. PMID: 35026477
Solid papillary mesothelial tumor.
Churg A, Le Stang N, Dacic S, Pissaloux D, Begueret H, Dartigues P, Giusiano-Courcambeck S, Sequeiros R, Pairon JC, Tirode F, Galateau-Sallé F
Mod Pathol 2022 Jan;35(1):69-76. Epub 2021 Sep 3 doi: 10.1038/s41379-021-00899-3. PMID: 34480081
Pleural neoplastic pathology.
Karpathiou G, Stefanou D, Froudarakis ME
Respir Med 2015 Aug;109(8):931-43. Epub 2015 May 21 doi: 10.1016/j.rmed.2015.05.014. PMID: 26048082
Pathohistological diagnosis and differential diagnosis.
Tischoff I, Neid M, Neumann V, Tannapfel A
Recent Results Cancer Res 2011;189:57-78. doi: 10.1007/978-3-642-10862-4_5. PMID: 21479896

Therapy

Malignant peritoneal mesothelioma in patients with endometriosis.
Butnor KJ, Rueckert J, Pavlisko EN, Sporn TA, Roggli VL
J Clin Pathol 2018 Nov;71(11):971-974. Epub 2018 May 23 doi: 10.1136/jclinpath-2018-205099. PMID: 29794065
Therapeutic strategies for well-differentiated papillary mesothelioma of the peritoneum.
Lee YK, Jun HJ, Nahm JH, Lim TS, Park JS, Ahn JB, Rha SY, Chung HC, Oh HE, Song JS, Yang WI, Kim HS
Jpn J Clin Oncol 2013 Oct;43(10):996-1003. Epub 2013 Aug 20 doi: 10.1093/jjco/hyt117. PMID: 23964112
Peritoneal mesothelioma: the site of origin matters.
Kindler HL
Am Soc Clin Oncol Educ Book 2013:182-8. doi: 10.14694/EdBook_AM.2013.33.182. PMID: 23714495
Well-differentiated papillary mesothelioma of the pleura: a series of 24 cases.
Galateau-Sallé F, Vignaud JM, Burke L, Gibbs A, Brambilla E, Attanoos R, Goldberg M, Launoy G; Mesopath group
Am J Surg Pathol 2004 Apr;28(4):534-40. doi: 10.1097/00000478-200404000-00013. PMID: 15087673
Pathology of malignant mesothelioma.
Attanoos RL, Gibbs AR
Histopathology 1997 May;30(5):403-18. doi: 10.1046/j.1365-2559.1997.5460776.x. PMID: 9181361

Prognosis

The 2021 WHO Classification of Tumors of the Pleura: Advances Since the 2015 Classification.
Sauter JL, Dacic S, Galateau-Salle F, Attanoos RL, Butnor KJ, Churg A, Husain AN, Kadota K, Khoor A, Nicholson AG, Roggli V, Schmitt F, Tsao MS, Travis WD
J Thorac Oncol 2022 May;17(5):608-622. Epub 2022 Jan 10 doi: 10.1016/j.jtho.2021.12.014. PMID: 35026477
Solid papillary mesothelial tumor.
Churg A, Le Stang N, Dacic S, Pissaloux D, Begueret H, Dartigues P, Giusiano-Courcambeck S, Sequeiros R, Pairon JC, Tirode F, Galateau-Sallé F
Mod Pathol 2022 Jan;35(1):69-76. Epub 2021 Sep 3 doi: 10.1038/s41379-021-00899-3. PMID: 34480081
Pleural neoplastic pathology.
Karpathiou G, Stefanou D, Froudarakis ME
Respir Med 2015 Aug;109(8):931-43. Epub 2015 May 21 doi: 10.1016/j.rmed.2015.05.014. PMID: 26048082
Pathohistological diagnosis and differential diagnosis.
Tischoff I, Neid M, Neumann V, Tannapfel A
Recent Results Cancer Res 2011;189:57-78. doi: 10.1007/978-3-642-10862-4_5. PMID: 21479896
Well-differentiated papillary mesothelioma.
Butnor KJ, Sporn TA, Hammar SP, Roggli VL
Am J Surg Pathol 2001 Oct;25(10):1304-9. doi: 10.1097/00000478-200110000-00012. PMID: 11688466

Clinical prediction guides

Clinicopathological Characteristics of Well-differentiated Papillary Mesothelioma of The Peritoneum: A Single-institutional Experience of 12 Cases.
Kim M, Kim HS
In Vivo 2019 Mar-Apr;33(2):633-642. doi: 10.21873/invivo.11521. PMID: 30804152Free PMC Article
Well-Differentiated Papillary Mesothelioma of the Peritoneum: A Retrospective Study from the RENAPE Observational Registry.
Vogin G, Hettal L, Vignaud JM, Dartigues P, Goere D, Ferron G, Heyd B, Bereder JM, Tuech JJ, Glehen O, de Chaisemartin C, Lherm Y, Villeneuve L, Kepenekian V, Marchal F; RENAPE Network
Ann Surg Oncol 2019 Mar;26(3):852-860. Epub 2019 Jan 11 doi: 10.1245/s10434-018-07153-2. PMID: 30635798
Well-differentiated papillary mesothelioma with invasive foci.
Churg A, Allen T, Borczuk AC, Cagle PT, Galateau-Sallé F, Hwang H, Murer B, Murty VV, Ordonez N, Tazelaar HD, Wick M
Am J Surg Pathol 2014 Jul;38(7):990-8. doi: 10.1097/PAS.0000000000000200. PMID: 24618613
Therapeutic strategies for well-differentiated papillary mesothelioma of the peritoneum.
Lee YK, Jun HJ, Nahm JH, Lim TS, Park JS, Ahn JB, Rha SY, Chung HC, Oh HE, Song JS, Yang WI, Kim HS
Jpn J Clin Oncol 2013 Oct;43(10):996-1003. Epub 2013 Aug 20 doi: 10.1093/jjco/hyt117. PMID: 23964112
Well-differentiated papillary mesothelioma: a clinicopathological and immunohistochemical study of 18 cases with additional observation.
Chen X, Sheng W, Wang J
Histopathology 2013 Apr;62(5):805-13. doi: 10.1111/his.12089. PMID: 23530588

Recent systematic reviews

Well-Differentiated Papillary Mesothelioma of the Tunica Vaginalis: Case Report and Systematic Review of Literature.
Tan WK, Tan MY, Tan WS, Gan SC, Pathmanathan R, Tan HM, Tan WP
Clin Genitourin Cancer 2016 Aug;14(4):e435-9. Epub 2016 Mar 12 doi: 10.1016/j.clgc.2016.03.007. PMID: 27067374

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